![I've compared the prototype E3 gamepad against the retail version. Nintendo did make some changes after the E3 in 2011 when they exhibited the console. : r/wiiu I've compared the prototype E3 gamepad against the retail version. Nintendo did make some changes after the E3 in 2011 when they exhibited the console. : r/wiiu](https://preview.redd.it/3ufv30nxdlq61.jpg?width=640&crop=smart&auto=webp&s=47f92ec638c39c91c0bc26229d688e4e347981af)
I've compared the prototype E3 gamepad against the retail version. Nintendo did make some changes after the E3 in 2011 when they exhibited the console. : r/wiiu
![I've compared the prototype E3 gamepad against the retail version. Nintendo did make some changes after the E3 in 2011 when they exhibited the console. : r/wiiu I've compared the prototype E3 gamepad against the retail version. Nintendo did make some changes after the E3 in 2011 when they exhibited the console. : r/wiiu](https://i.redd.it/97xopzmxdlq61.jpg)
I've compared the prototype E3 gamepad against the retail version. Nintendo did make some changes after the E3 in 2011 when they exhibited the console. : r/wiiu
![Protein quality control: U-box-containing E3 ubiquitin ligases join the fold: Trends in Biochemical Sciences Protein quality control: U-box-containing E3 ubiquitin ligases join the fold: Trends in Biochemical Sciences](https://www.cell.com/cms/attachment/556513/3982472/gr1.jpg)
Protein quality control: U-box-containing E3 ubiquitin ligases join the fold: Trends in Biochemical Sciences
![Diagrammatic representation of E3 types. From top, U box-, RING-, RBR-,... | Download Scientific Diagram Diagrammatic representation of E3 types. From top, U box-, RING-, RBR-,... | Download Scientific Diagram](https://www.researchgate.net/publication/266974309/figure/fig4/AS:295687913787403@1447508900499/Diagrammatic-representation-of-E3-types-From-top-U-box-RING-RBR-HECT-type-E3s.png)